Rapid pain reduction by the use of local wIRA therapy (hydrosun®-750 irradiator) in the treatment of axial spondyloarthritis - a Randomized Clinical Trial

Patients with active disease undergoing a 7-day multimodal rheumatologic complex treatment under non-steroidal anti-inflammatory drug (NSAID) therapy were randomised. The interventional group (IG) received additional  serial local wIRA treatment of the back (2 treatments for 30 min per day for 6 days). 36 patients of the IG and 35 patients of the control group (CG) completed the trial.

Multimodal rheumatologic complex treatment including wIRA application (IG) or not (CG) resulted both in a significant reduction in disease activity and functional indexes.

However, TNF-α levels were significantly decreased only in the wIRA-IG with a significant difference to the CG. Due to a rapid reduction in pain, 26 (76%) patients in the wIRA-IC reduced or even stopped their NSAID drug therapy after trial completion, compared to only 1 patient of the CG. A reason for these desirable effects of wIRA therapy could be the described change in TNF-α levels.

The publication of Klemm P, Eichelmann M, Aykara I, Hudowenz O, Dischereit G, Lange U is open access available at


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