Table of Content:





Charite University Berlin, Department of Radiation Oncology and Radiotherapy
Potential of Moderate Whole Body Hyperthermia to Enhance Response (POWER)

Massachusetts General Hospital Boston / USA
Peripheral Neuroimmune Mechanisms of Hyperthermia

Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Germany
Department of Psychiatry, Psychotherapy and Addiciton Medicine, Kliniken Essen-Mitte
Whole-body Hyperthermia for Mild to Moderate Depressive Disorder (HYPE1)
Whole-body Hyperthermia for Moderate to Severe Depressive Disorder (HYPE2)
Informationen zur Studie und Studienteilnahme [GERMAN]
Flyer zur Hyperthermiestudie [GERMAN]

Charite University Berlin, Department of Psychiatry and Psychotherapy 
A randomized, double-blind controlled study of the efficacy of infrared-whole body hyperthermia in patients with major depression
Informationen zur Studie und Studienteilnahme [GERMAN]




1. Clinical studies using heckel WBH systems

Flux MC, Smith DG, Allen JJB, Mehl MR, Medrano A, Begay TK, Middlemist BH, Marquart BM, Cole SP, Sauder CJ, Lowry CA, Raison CL:
Association of plasma cytokines and antidepressant response following mild-intensity whole-body hyperthermia in major depressive disorder    
Transl Psychiatry. 2023 Apr 21;13(1):132.

Janssen CW, Lowry CA:Janssen CW, Lowry CA, Mehl MR, Allen JJ, Kelly KL, Gartner DE, Medrano A, Begay TK, Rentscher K, White JJ, Fridman A, Roberts LJ, Robbins ML, Hanusch KU, Cole SP, Raison CL:
Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial    
JAMA Psychiatry. 2016 Aug 1;73(8):789-95

Raison CL, Janssen CW, Lowry CA:
Hyperthermia for Major Depressive Disorder?-Reply
JAMA Psychiatry. 2016 Oct 1;73(10):1096-1097

Hanusch KU, Janssen CH, Billheimer D, Jenkins I, Spurgeon E, Lowry CA, Raison CL:
Whole-Body Hyperthermia for the Treatment of Major Depression: Associations With Thermoregulatory Cooling
Am J Psychiatry 170:7, July 2013

2. Clinical studies using other WBH techniques

Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R:
Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial
BMC Complement Altern Med. 2017; 17: 172

3. Reviews, overviews, book chapters

Knobel A, Hanusch K, Auen N, Rübener F, Fischer S, Borzim C, Heinz A, Schäfer M:
Whole-Body Hyperthermia (WBH) in Psychiatry
In: Water-filtered Infrared A (wIRA) Irradiation (Ed.: P. Vaupel), pp. 155-164. Springer Nature Switzerland, Cham. DOI: 10.1007/978-3-030-92880-3_12

Hanusch KU, Janssen CW:
The impact of wholebody hyperthermia interventions on mood and depression – are we ready for recommendations for clinical application?
International Journal of Hyperthermia, 2019, 36:1, 573-581, DOI: 10.1080/02656736.2019.1612103

Woesner ME:
What is old is new again: The use of whole-body hyperthermia for depression recalls the medicinal uses of hyperthermia, fever therapy, and hydrotherapy.
Curr Neurobiol 2019; 10(2): 56-66.

Hanusch KU, Janssen CH:
Die Ganzkörperhyperthermie in der Psychiatrie - Eine historische Analyse
[ARTICLE IN GERMAN] Die Naturheilkunde 02/2013

Hanusch KU:
“Antidepressive” Effect through Heat Therapy - Influence of the psychical condition of depressive patients through passive whole-body hyperthermia.
MASTER'S THESIS, Clinical Psychoneuroimmunology, University of Girona (UdG) / University of Graz, Uni4Life, Nov. 2012

Janssen C, Hanusch KU:
Passive Ganzkörperhyperthermie bei Depressionen
[ARTICLE IN GERMAN] Die Naturheilkunde 05/2011





1. Clinical studies using heckel WBH systems

Schmidt R:
Studie zur ambulanten moderaten Ganzkörperhyperthermie bei Fibromyalgiesyndrom (Vorstellung des Studiendesigns)
[ARTICLE IN GERMAN] Erfahrungsheilkunde 2022; 71(03): 158-165; DOI: 10.1055/a-1789-2165

Romeyke T, Stummer H:
Multi-Modal Pain Therapy of Fibromyalgia Syndrome with Integration of Systemic Whole-Body Hyperthermia – Effects on Pain Intensity and Mental State: A Non-Randomised Controlled Study
Journal of Musculoskeletal Pain Vol: 22, Issue 4, December 2014, pages 341-355

Romeyke T, Scheuer HC, Stummer H:
Fibromyalgia with severe forms of progression in a multidisciplinary therapy setting with emphasis on hyperthermia therapy--a prospective controlled study    
Clin Interv Aging. 2014 Dec


2. Clinical studies using other WBH systems

Brockow T, Wagner A, Franke A, Offenbächer M, Resch KL:
A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthermia as an adjunct to a standard multimodal rehabilitation in the treatment of fibromyalgia.
Clin J Pain. 2007 Jan;23(1):67-75


3. Clinical case reports using heckel WBH systems

Winnicki C, Hanusch KU:
Hyperthermie gegen Fibromyalgiesyndrom
Schweiz Z Ganzheitsmed 2013;25:267-268


4. Others

Häuser W, Jung E, Erbslöh-Möller B,Gesmann M, Kühn-Becker H,Petermann F, Langhorst J, Thoma R, Weiss T, Wolfe F, Winkelmann A:
The German fibromyalgia consumer reports – a cross-sectional survey
BMC Musculoskelet Disord. 2012; 13: 74


5. Congress abstracts

Romeyke T:
Systemic whole-body hyperthermia: a therapy option for the treatment of fibromyalgia?
The 4th International Virtual Congress on Controversies in Fibromyalgia - Poster Presentations - P14, page 20
Clinical and Experimental Rheumatology 2022



Oncology (A) fever-range WBH


1. Clinical studies using heckel WBH systems

Hohneck AL, Sadikaj L, Heinemann L, Schroeder M, Riess H, Gerhards A, Burkholder I, Heckel-Reusser S, Gottfried J, Hofheinz RD:
Patients with Advanced Pancreatic Cancer Treated with Mistletoe and Hyperthermia in Addition to Palliative Chemotherapy: A Retrospective Single-Center Analysis.    
Cancers (Basel). 2023 Oct 11;15(20):4929. doi: 10.3390/cancers15204929.

Zschaeck S, Weingärtner J, Ghadjar P, Wust P, Mehrhof F, Kalinauskaite G, Ehrhardt VH, Hartmann V, Tinhofer I, Heiland M, Coordes A, Kofla G, Budach V, Stromberger C, Beck M:
Fever range whole body hyperthermia for re-irradiation of head and neck squamous cell carcinomas: Final results of a prospective study    
Oral Oncol. 2021 Feb 21;116:105240. Online ahead of print.

Rogasch J, Beck M, Stromberger C, Hofheinz F, Ghadjar P, Wust P, Budach V, Amthauer H, Tinhofer I, Furth C, Walter-Rittel TC, Zschaeck S:
PET measured hypoxia and MRI parameters in re-irradiated head and neck squamous cell carcinomas: findings of a prospective pilot study
F1000Res. 2020 Nov 19;9:1350

Kleef R, Nagy R, Baierl A, Bacher V, Bojar H, McKee DL, Moss R, Thoennissen NH, Szász M, Bakacs T
Low-dose ipilimumab plus nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series of 131 stage IV cancers - a retrospective study of a single institution    
Cancer Immunol Immunother. 2020

Kobayashi Y, Itoa Y, Ostapenko VV, Sakai M, Matsushita N, Imai K, Shimizu K, Aruga A,Tanigawa K:
Fever-range whole-body heat treatment stimulates antigen-specificT-cell responses in humans
Immunology Letters 162 (2014) 256–261

Sulyok I, Fleischmann E, Stift A, Roth G, Lebherz-Eichinger D, Kasper D, Spittler A, Kimberger O:
Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery
Br J Anaesth. 2012 Nov;109(5):754-61

Bull JM, Scott GL, Strebel FR, Nagle VL, Oliver D, Redwine M, Rowe RW, Ahn CW, Koch SM:
Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-alpha: a description of a phase I-II protocol.
Int J Hyperthermia. 2008 Dec;24(8):649-62

Kraybill WG, Olenki T, Evans SS, Ostberg JR, O'Leary KA, Gibbs JF, Repasky EA:
A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models.
Int J Hyperthermia. 2002 May-Jun;18(3):253-66


2. Clinical case reports using heckel WBH systems

Kleef R, Bacher V, Nagy R, Reisegger P, Bakacs T:
Complete Remission of Vocal Cord Cancer Treated With Low-Dose Ipilimumab Plus Nivolumab Combined With Interleukin-2 and Hyperthermia
Cureus. 2021 Apr 15;13(4):e14500. doi: 10.7759/cureus.14500.

Kleef R, Moss R, Szasz AM, Bohdjalian A, Bojar H, Bakacs T:
Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2
Integr Cancer Ther. 2018 Dec; 17(4): 1297–1303.

Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK:
Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer.
Int J Hyperthermia. 2016 Aug;32(5):539-42, LETTER TO THE EDITOR

Kleef R, Kekic S, Ludwig N:
Successful Treatment of Advanced Ovarian Cancer with Thermochemotherapy and Adjuvant Immune Therapy
Case Rep Oncol 2012;5:212–215


3. Pre-clinical studies

Rowe RW, Strebel FR, Proett JM, Deng W, Chan D, He G, Siddik ZH, Bull JMC:
Fever-Range Whole-body Thermotherapy Combined With Oxaliplatin: A Curative Regimen in a Preclinical Breast Cancer Model
Int J Hyperthermia. 2010; 26(6): 565–576


4. Reviews

Bull JMC:
A review of immune therapy in cancer and a question: can thermal therapy increase tumor response?
Int J Hyperthermia. 2018 Sep;34(6):840-852.

Yagawa Y, Tanigawa K, Kobayashi Y, Yamamoto M:
Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery.
J Cancer Metastasis Treat 2017;3:218-30

Repasky EA, Evans SS, Dewhirst M:
Temperature Matters! And Why it Should Matter to Tumor Immunologists.
Cancer Immunol Res. 2013 Oct 1; 1(4)

Faghihi Moghadam F, Bakhshandeh M, Sahinbas H:
Hyperthermia: A Neoadjuvant Therapeutic Approach in Cancer Treatment
CANCERPRESS Vol. 3, No.1, March, 2017


5. Books, book chapters

Zschaeck S, Beck M:
Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?
In: Water-filtered Infrared A (wIRA) Irradiation (Ed.: P. Vaupel), pp. 107-115. Springer Nature Switzerland, Cham. DOI: 10.1007/978-3-030-92880-3_8


Tanigawa K, Ito Y, Kobayashi Y:
Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy
in: S. Kokura et al. (eds.), Hyperthermic Oncology from Bench to Bedside, Springer Science+Business Media Singapore 2016

Rowe-Horwege W:
Hyperthermia, Systemic
in Enceclopedia of Medical Devices and Instrumentation, Second Edition, 2006 John Wiley & Sons, Inc.


6. Congress abstracts:

Kleef R, Nagy R, Bacher V, Bakacs T, Lausch T, McKee D, Moss R, Bojar H, Thoennissen N:
Low-dose checkpoint inhibitors with hyperthermia and IL-2 are safe and effective in stage IV cancer with unfavourable immunological profile (MSI low, PD-L1 under 1%, TMB low) – A single-institution experience from 2015 to 2020
The 7th leading International Cancer Immunotherapy Conference in Europe, 2–4 October 2020, virtual conference, P08.01
J Immunother Cancer 2020;8(Suppl 2):A1–A67
PDF Download

Kleef R, Nagy R, Bohdjalian A, Bacher V, Kekic A, Kekic S, McKee D, Bojar H, Moss R:
Complete response of stage IV pancreatic cancer combining dose adapte d checkpoint inhibitors with interleukin 2 (IL 2) and fever range hyperthermia
PDF Download

Kleef R:
Coley remembered – back to the roots. Fevertherapy of cancer in the light of modern immunology.
Abstract - Medizinische Woche Baden-Baden 03.10.-03.11.2019
PDF Download

Kleef R, Nagy R, Bohdjalian A, Bacher V, Wychera A, Kekic S, McKee D, Bojar H, Moss R:
Complete response of stage IV pancreatic cancer combining low-dose checkpoint inhibitors with interleukin-2 (IL-2) and fever range hyperthermia
The 6th Leading International Cancer Immunotherapy Conference in Europe / European Journal of Cancer 110 (2019) S22

Wey S:
14 years fever-range whole body hyperthermia in adjuvant recurrence prophylaxis of breast cancer.
ESHO 2018 Berlin, P 12 , p. 495

Wey S:
Secondary and tertiary recurrence prevention with fever range whole-body hyperthermia in (metastatic) malignant melanoma.
ESHO 2018 Berlin, P 13 , p. 496

Kleef R, Bojar H, Moss R, Stix A, Bohdjalian A, Bacher V, Nagy R, McKee D:
Exogenous and endogenous hyperthermia combining lowdose checkpoint inhibitors with interleukin-2 (IL-2) and fever range whole body and local regional hyperthermia in stage IV cancer.
ESHO 2018 Berlin, P 35 , p. 504

Pinto J, Ferreira A, Ferreira C, Cruz A, Pinto M:
Fever-range whole body hyperthermia with concomitant capecitabine in third line therapy for BRCA mutated metastatic breast cancer.
ESHO 2018 Berlin, P 38 , p. 506

Kleef R, Bohdjalian A, McKee D, Moss RW:
Complete response of stage IIIB esophageal cancer combining low-dose checkpoint inhibitors with interleukin-2 (IL-2) and fever range hyperthermia.
4th ImmunoTherapy of Cancer Conference, Prague, Czech Republic. 20–22 March 2017, A39
J Immunotherapy Cancer 5, 12 (2017).

Kleef R:
Low-dose checkpoint inhibitor therapy with interleukin-2 (IL-2) and fever range hyperthermia in stage IV cancer: a retrospective analysis with single case presentations
ESHO 2017 21-23 June Athens, Greece, Abstracts OP-10

Kleef R, Bohdjalian A, McKee D, Moss RW:
Complete response of stage IIIB esophageal cancer combining low-dose checkpoint inhibitors with interleukin-2 (IL-2) and fever range hyperthermia.
Journal for ImmunoTherapy of Cancer 2017, 5(Suppl 1):12 DOI 10.1186/s40425-017-0219-4 , A39, p.15

Kleef R, Moss RW, Szasz AM, Bohdjalian A, Bakacs T:
Near complete remission of pulmonary metastases in triple negative breast cancer (TNBC) using low-dose immune checkpoint (IC) inhibitors with high dose (HD) interleukin-2 (IL-2) and fever range hyperthermia
EJC, Vol55, Suppl.1, March 2016; 3rd Immunotherapy of Cancer Conference 21–23 March, 2016, Munich/Germany


Oncology (B) extreme WBH

1. Clinical studies using heckel WBH systems

Changlin Zhao , Congqi Dai, Xiaoyin Chen:
Whole body hyperthermia combined with intraperitoneal chemotherapy for the treatment of stage IV advanced gastric cancer
Int.J.Hyperthermia, December 2012; 28(8): 735-741

Douwes F, Bogovic J, Douwes O, Migeod F, Grote C:
Whole body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer
Int J Clin Oncol. 2004 Apr;9(2):85-91

Gaworek J, Mayer CT:
Systemische Ganzkörperhyperthermie in der Onkologie: Tödliche Hitze für Tumorzellen
[Systemic whole body hyperthermia in oncology: fatal heat for tumor cells].

Pflege Z. 2003 Jan;56(1):15-8

Reichel M, Scheeren TWL, Douwes O, Konrad RM:
Tiefe intravenöse Analgosedierung zur extremen Ganzkörperhyperthermie in Kombination mit Chemotherapie
[Deep intravenous analgosedation for extreme whole-body hyperthermia in combination with chemotherapy]

Forum Komplementäre Onkologie & Forum Immunologie, 3/2004, 4-8






Chronic inflammation / chronic infection

1. Clinical studies using heckel WBH systems

Douwes F:
Komplextherapie der chronischen Borreliose (Lyme Disease) - Ein neuer Therapieansatz: die Antibiotika augmentierte Thermoeradikation (AAT).
OM & Ernährung 2018 / Nr. 164 [Article in German]

Douwes F:
The successful antibiotic augmented thermal eradication of chronic lyme disease.
ESHO 2018 Berlin, P 43

Zauner D, Quehenberger F, Hermann J, Dejaco C, Stradner M, Stojakovic T, Angerer H, Rinner B, Graninger WB:
Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis:A pilot study
Int J Hyperthermia, 2014; 30(6): 393–401

Fuchs, Y:
Effekte einer moderaten Infrarot- Ganzkörper- Hyperthermie auf die Akut- Phase Reaktion
Diplomarbeit Medical University of Graz; 2010. pp. 73

Hanusch KU, Janssen CH, Gluch A:
Passive Infrarot-A-Ganzkörperhyperthermie (Heckelbett) bei rheumatischen Erkrankungen
Schweiz Z Ganzheitsmed 2011;23:327–330


2. Pre-clinical studies

Lee CT, Kokolus KM, Leigh ND, Capitano M, Hylander BL, Repasky EA:
Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis.
PLoS One. 2015 Mar 20;10(3):e0120327

Reisinger E, Wendelin I, Gasser R, Halwachs G, Wilders-Truschnig M, Krejs G:
Antibiotics and Increased Temperature against Borrelia burgdorferi in Vitro
Scandinavian Journal of Infectious Diseases, Vol.28, 1996, Issue 2, pp. 155-157





Others, general review and overview articles

Heckel-Reusser S:
Whole-Body Hyperthermia (WBH): Historical Aspects, Current Use, and Future Perspectives.
In: Water-filtered Infrared A (wIRA) Irradiation (Ed.: P. Vaupel), pp. 143-154. Springer Nature Switzerland, Cham. DOI: 10.1007/978-3-030-92880-3_11

Kok HP, Cressman ENK, Ceelen W, Brace CL, Ivkov R, Grüll H, Ter Haar G, Wust P, Crezee J:
Heating Technology for Malignant Tumors: A Review.
Int J Hyperthermia. 2020;37(1):711-741. doi: 10.1080/02656736.2020.1779357

Evans SS, Repasky EA, Fischer DT:
Fever and the thermal regulation of immunity: the immune system feels the heat.
Nat Rev Immunol. 2015 Jun; 15(6)

Kleef R:
Hyperthermie und Entgiftung
OM & Ernährung 2011 / Nr.135

Heckel M, Dickreiter B:
Ganzkörperhyperthermie – Kontrollierte Erhöhung der Körpertemperatur zu therapeutischen Zwecken
Natur-Heilkunde Journal, 10+11/2007



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