RT = Radiotherapy
HT = Hyperthermia

Table of Content:



wIRA superficial HT

Notter M, Stutz E, Thomsen AR, Kollár A, Vaupel P:
Comment on Kronenfeld et al. Clinical Outcomes for Primary and Radiation-Associated Angiosarcoma of the Breast with Multimodal Treatment: Long-Term Survival Is Achievable. Cancers 2021, 13, 3814
Cancers 2021, 13(22), 5707; - 15 Nov 2021
Original article which is commented:

Notter M, Stutz E, Thomsen AR, Vaupel P:
Radiation-Associated Angiosarcoma of the Breast and Chest Wall Treated with Thermography-Controlled, Contactless wIRA-Hyperthermia and Hypofractionated Re-Irradiation
Cancers 2021, 13(15), 3911; doi: 10.3390/cancers13153911

Wan Fatin Amira Wan Mohd Zawawi, Hibma MH, Salim MI, Jemon K:
Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor.
Sci Rep. 2021 May 13;11(1):10278. doi: 10.1038/s41598-021-89740-0.

Notter M, Thomsen AR, Grosu A-L, Vaupel P.:
Recommendation of Regional Hyperthermia in the Treatment of Breast Cancer.
Integrative Cancer Therapies. 2021 Jan. doi:10.1177/1534735420988606

Fiorentini G, Sarti D, Gadaleta CD, et al.:
Re: Response to Recommendation of Regional Hyperthermia in the Treatment of Breast Cancer.
Integrative Cancer Therapies. 2021 Jan. doi:10.1177/1534735420988589

Buchholz TA, Ali S, Hunt KK:
Reply to Thomsen A. et al.
J Clin Oncol.  2020 Sep 8;JCO2002247. doi: 10.1200/JCO.20.02247

Thomsen AR, Vaupel P, Grosu AL, Notter M:
Hyperthermia Plus Re-Irradiation in the Management of Unresectable Locoregional Recurrence of Breast Cancer in Previously Irradiated Sites.
J Clin Oncol. 2020 Sep 8;JCO2001857. doi: 10.1200/JCO.20.01857

Buchholz TA, Ali S, Hunt KK:
Multidisciplinary Management of Locoregional Recurrent Breast Cancer.
J Clin Oncol. 2020 Jul 10;38(20):2321 doi:10.1200/JCO.19.02806 

Piazena H, Müller W, Vaupel P:
wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia.
Intl J Hyperthermia. 2020; 37(1): 887-896

Notter M, Thomsen AR, Nitsche M, Hermann RM, Wolff H, Habl G, Münch K, Grosu AL, Vaupel P:
Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification.
Cancers 2020, 12, 606; doi:10.3390/cancers12030606

Piazena H, Müller W, Pendl W, von Ah S, Cap VH, Hug PJ, Sidler X, Pluschke G, Vaupel P:
Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens.
Int J Hyperthermia. 2019;36(1):938-952. doi: 10.1080/02656736.2019.1655594.

Notter M:
Hyperthermie und Radiotherapie bei Hauttumoren - Grundlagen, Anwendung, Studienlage beim Melanom, Angiosarkom und Merkelzellkarzinom.

Vaupel P, Piazena H, Müller W, Notter M:
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Int J Hyperthermia, Volume 35, 2018 - Issue 1, pp. 26–36

Notter M, Piazena H, Vaupel P:
Hypofractionated re-irradiation of large-sized re-current breast cancer with thermography-controlled, contact-free water-filtered infrared-A hyperthermia: A retrospective study of 73 patients.
International Journal of Hyperthermia Volume 33, 2017 - Issue 2, pp. 227-236

Dombrovsky LA, Timchenko V, Pathak C, Piazena H, Müller W, Jackson M:
Radiative heating of superficial human tissues with the use of water-filtered infrared-A radiation: A computational modeling.
International Journal of Heat and Mass Transfer 85 (2015) 311–320

Stutz E, Puric E, Datta NR, Bodis S, Notter M:
Radiation-Associated Angiosarcoma of the Breast - What can we learn from case reports?
Strahlenassoziiertes Angiosarkom der Brust - Was können wir aus Fallberichten lernen?
InFo ONKOLOGIE & HÄMATOLOGIE 2017; Vol. 5, Nr. 4
OPEN ACCESS after free registration
[Article in German]

Seegenschmiedt MH, Klautke G, Walther E, Feldmann HJ, Katalinic A, Stuschke M, von Lieven H, Vaupel P:
Water-filtered infrared-A-hyperthermia combined with radiotherapy in advanced and recurrent tumors. Initial results of a multicenter phase I-II study.
Strahlenther Onkol. 1996 Sep;172(9):475-84.
[Article in German]

Vaupel P, Kelleher DK, Krüger W:
Water-filtered infrared-A radiation: a novel technique to heat superficial tumors
Strahlenther Onkol. 1992 Nov; 168(11):633-9


Congress abstracts:

Thomsen A, Saalmann M, Kollefrath M, Grosu AL, Nicolay NH, Scholber J, Notter M, Vaupel P
Oxygenation status in human skin and subcutis upon thermography-controlled wIRA-hyperthermia: Implications for thermoradiation of superficial cancers
DEGRO 2020, Abstract P04-5
Strahlenther Onkol (2021) (Suppl 1) 197:S1–S246

Thomsen AR, Vaupel P, Nitsche M, Hermann RM, Wolff HA, Habl G, Grosu AL, Notter M:
wIRA-hyperthermia and hypofractionated re-irradiation: A new treatment option for inoperable, large-sized locally recurrent breast cancer
DEGRO 2020, Abstract HL08-5
Strahlenther Onkol (2020) (Suppl 1) 196:S1–S230

Notter M, Thomsen AR, Vaupel P:
Radiation-associated angiosarcoma of the breast: Benefit of adjuvant re-irradiation with preceding wIRA-hyperthermia
DEGRO 2020, Abstract P13-2
Strahlenther Onkol (2020) (Suppl 1) 196:S1–S230

Rühle A, Thomsen A, Saffrich R, Wuchter P, Vaupel P, Huber PE, Grosu AL, Nicolay NH:
Auswirkungen von Hyperthermie alleine und in Kombination mit ionisierender Strahlung auf humane mesenchymale Stammzellen
DEGRO 2020, Abstract SYV16-6-jD
Strahlenther Onkol (2020) (Suppl 1) 196:S1–S230

Scholber J, Nicolay NH, Grosu AL, Kollefrath M, Vaupel P, Thomsen AR:
Synergistische Wirkung von hypofraktionierter Strahlentherapie, wIRA-Hyperthermie und antihormoneller Therapie – ein bemerkenswerter Verlauf eines Patienten mit kutan metastasiertem Speicheldrüsenkarzinom
DEGRO 2020, Abstract P15-2
Strahlenther Onkol (2020) (Suppl 1) 196:S1–S230

Crezee J, Zweije R, Bakker A, van Tienhoven G, Kok HP:
Combining 70MHz and 434MHz or wIRA Hyperthermia Applicators for Optimal Coverage of Semi-Deep Tumour Sites
2019 49th European Microwave Conference (EuMC), 2019, pp. 164-167, doi: 10.23919/EuMC.2019.8910796.

Saalmann M, Thomsen AR, Kollefrath M, Grosu AL, Vaupel P:
Einfluss von Tumor-Ulzerationen auf die Applikation und thermographische Überwachung der Oberflächen-Hyperthermie mit wassergefilterter Infrarot A-Strahlung
DEGRO 2019, Abstract P20-10-jD
Strahlenther Onkol (2019) (Suppl 1) 195:S1–S218 - Seite 148,

Notter M, Vaupel P:
Combined wIRA-hyperthermia and repeat re-irradiation (re-re-RT) in the management of re-recurrences of locally recurrent breast cancer
Abstract 33rd Annual Meeting of the European Society of Hyperthermic Oncology 2019
ESHO Abstract 2019

Thomsen AR, Saalmann M, Nicolay NH, Grosu AL, Vaupel P:
Monitoring of key parameters during thermography-controlled wIRA-hyperthermia in the treatment of superficial tumors
Abstract 33rd Annual Meeting of the European Society of Hyperthermic Oncology 2019
ESHO Abstract 2019

Thomsen AR, Aldrian C, Niedermann G, Grosu AL, Vaupel P, Lund PG:
Differential effects of 42°C-hyperthermia on radiation response of breast cancer spheroids vs. normal human skin explants
Abstract 36th Annual Meeting of the Society of Thermal Medicine 2019
ESHO Abstract 2019

Lund PG, Aldrian C, Grosu AL, Niedermann G, Vaupel P, Thomsen AR:
42°C- hyperthermia sensitizes breast cancer spheroids to hypofractionated irradiation, but not normal epidermal cell cultures. DEGRO 2018 Abstract V03-4.
Strahlentherapie und Onkologie - Sonderheft 1/2018

Notter M, Vaupel P:
Re-irradiation and wIRA-hyperthermia for superficial widespread breast cancer recurrences: an up-date.
ESHO Congress 2017 Athen, Oral presentation, OPEN ACCESS Abstract OP-04, p.59,

Piazena H:
Water-filtered infrared-A (wIRA) in superficial hyperthermia – physical and photo-biological basics.
ESHO Congress 2017 Athen, Oral presentation, OPEN ACCESS Abstract OP-05, p.60,

Thomsen AR, Aldrian C, Heselich A, Niedermann G, Grosu AL, Lund PG:
Hyperthermia with water-filtered infrared A sensitizes breast cancer spheroids to hypofractionated irradiation, but not normal epidermal cell cultures
ESHO Congress 2017 Athen, Poster presentation, Abstract PP-25

Thomsen AR, Aldrian C, Nanko N, Heselich A, Niedermann G, Lund P:
Fraktionierte Strahlentherapie von Mamma-Karzinom-Sphäroiden in Kombination mit wassergelterter Infrarot A-Hyperthermie (wIRA).
Abstracts DEGRO 2016, P08-6, Strahlenther Onkol (2016) (Suppl) 192:92




Thermography in superficial HT

Müller J, Hartmann J, Bert C:
Infrared camera based thermometry for quality assurance of superficial hyperthermia applicators.
Phys Med Biol. 2016 Apr 7;61(7):2646-64



Reviews on combined RT/HT of locally recurrent breast cancer


Youssef I, Amin NP:
Radiation Therapy, Hyperthermia for Chest Wall Recurrence.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 - 2018 Oct 27.

Kaidar-Person O, Oldenborg S, Poortmans P:
Re-irradiation and Hyperthermia in Breast Cancer.
Clin Oncol (R Coll Radiol). 2018 Feb;30(2):73-84. doi: 10.1016/j.clon.2017.11.004. Epub 2017 Dec 8.

Marta GN, Hijal T, de Andrade Carvalho H:
Reirradiation for locally recurrent breast cancer.
Breast. 2017 Jun;33:159-165. doi: 10.1016/j.breast.2017.03.008. Epub 2017 Apr 7. Review.

Wadasadawala T, Vadgaonkar R, Bajpai J:
Management of Isolated Locoregional Recurrences in Breast Cancer: A Review of Local and Systemic Modalities.
Clin Breast Cancer. 2017 Nov;17(7):493-502. doi: 10.1016/j.clbc.2017.03.008. Epub 2017 Mar 21. Review.

Datta NR, Puric E, Klingbiel D, Gomez S, Bodis S:
Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis.
Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1073-87.

Maluta S, Kolff MW:
Role of Hyperthermia in Breast Cancer Locoregional Recurrence: A Review.
Breast Care (Basel). 2015 Dec;10(6):408-12. doi: 10.1159/000440792. Epub 2015 Oct 16. Review.

Kouloulias V, Triantopoulou S, Uzunoglou N, Pistevou-Gompaki K, Barich A, Zygogianni A, Kyrgias G, Kardamakis D, Pectasidis D, Kouvaris J:
Hyperthermia is now included in the NCCN Clinical Practice Guidelines for Breast Cancer Recurrences: An analysis of existing data.
Breast Care 2015, 10:109-116

Zagar TM, Oleson JR, Vujaskovic Z, Dewhirst MW, Craciunescu OI, Blackwell KL, Prosnitz LR, Jones EL:
Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data.
Int J Hyperthermia. 2010;26(7):612-7.

Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S:
Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future.
Cancer Treat Rev. 2015 Nov;41(9):742-53




Trials /analyses on combined RT/HT of locally recurrent breast cancer

Randomised trials


Jones EL, Oleson JR, Prosnitz LR, Samulski TV, Vujaskovic Z, Yu D, Sanders LL, Dewhirst MW:
Randomized trial of hyperthermia and radiation for superficial tumors.
J Clin Oncol. 2005 May 1;23(13):3079-85.

Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, van der Zee J, van Putten WL, van Rhoon GC, van Dijk JD, González González D, Liu FF, Goodman P, Sherar M:
Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group.
Int J Radiat Oncol Biol Phys. 1996 Jul 1;35(4):731-44.



Non randomised trials / retrospective analyses

Oldenborg S, van Os R, Oei B, Poortmans P
Impact of Technique and Schedule of Reirradiation Plus Hyperthermia on Outcome after Surgery for Patients with Recurrent Breast Cancer.
Cancers (Basel). 2019 Jun; 11(6): 782.

Dharmaiah S, Zeng J, Rao VS, Zi O, Ma T, Yu K, Bhatt H, Shah C, Godley A, Xia P, Yu JS:
Clinical and dosimetric evaluation of recurrent breast cancer patients treated with hyperthermia and radiation.
Int J Hyperthermia. 2019;36(1):986-992. doi: 10.1080/02656736.2019.1660810.

De-Colle C, Weidner N, Heinrich V, Brucker S, Hahn M, MacMillan K, Lamprecht U, Gaupp S, Voigt O, Zips D:
Hyperthermic chest wall re-irradiation in recurrent breast cancer: a prospective observational study.
Strahlenther Onkol. 2019 Jan 3. doi: 10.1007/s00066-018-1414-z. [Epub ahead of print]

Oldenborg S, Rasch CRN, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Heymans MW, Zum Vörde Sive Vörding PJ, Crezee H, van Tienhoven G:
Reirradiation + hyperthermia for recurrent breast cancer en cuirasse.
Strahlenther Onkol. 2018 Mar;194(3):206-214. doi: 10.1007/s00066-017-1241-7. Epub 2017 Dec 20.

Bakker A, Kolff MW, Holman R, van Leeuwen CM, Korshuize-van Straten L, de Kroon-Oldenhof R, Rasch CRN, van Tienhoven G, Crezee H:
Thermal Skin Damage During Reirradiation and Hyperthermia Is Time-Temperature Dependent.
Int J Radiat Oncol Biol Phys. 2017 Jun 1;98(2):392-399. doi: 10.1016/j.ijrobp.2017.02.009. Epub 2017 Feb 16.

Oldenborg S, Valk C, van Os R, Oei B, Venselaar J, Vörding PZ, van Randen A, Crezee H, van Tienhoven G, Rasch C:
Rib fractures after reirradiation plus hyperthermia for recurrent breast cancer: Predictive factors.
Strahlenther Onkol. 2016 Apr;192(4):240-7

Auoragh A, Strnad V, Ott OJ, Beckmann MW, Fietkau R:
Re-irradiation of the chest wall for local breast cancer recurrence : Results of salvage brachytherapy with hyperthermia.
Strahlenther Onkol. 2016 Sep;192(9):617-623.

Oldenborg S, Griesdoorn V, van Os R, Kusumanto YH, Oei BS, Venselaar JL, Zum Vörde Sive Vörding PJ, Heymans MW, Kolff MW, Rasch CR, Crezee H, van Tienhoven G:
Reirradiation and hyperthermia for irresectable locoregional recurrent breast cancer in previously irradiated area: Size matters.
Radiother Oncol. 2015 Nov;117(2):223-8

Datta NR, Puric E, Heuberger J, Marder D, Lomax N, Timm O, Memminger P, Bodis S:
Hyperthermia and reirradiation for locoregional recurrences in preirradiated breast cancers: a single institutional experience.
Swiss Med Wkly. 2015;145:w14133

Linthorst M, Baaijens M, Wiggenraad R, Creutzberg C, Ghidey W, van Rhoon GC, van der Zee J:
Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients.
Radiother Oncol. 2015 Nov;117(2):217-222

Refaat T, Sachdev S, Sathiaseelan V, Helenowski I, Abdelmoneim S, Pierce MC, Woloschak G, Small W Jr, Mittal B, Kiel KD:
Hyperthermia and radiation therapy for locally advanced or recurrent breast cancer.
Breast. 2015 Aug;24(4):418-25.

Harms W, Geretschläger A, Cescato C, Buess M, Köberle D, Asadpour B:
Current Treatment of Isolated Locoregional Breast Cancer Recurrences.
Breast Care (Basel). 2015 Aug;10(4):265-71.

Trujillo-Romero CJ, Paulides MM, Drizdal T, van Rhoon GC:
Impact of silicone and metal port-a-cath implants on superficial hyperthermia treatment quality.
Int J Hyperthermia. 2014 Dec 12:1-8.

Linthorst M, van Geel AN, Baaijens M, Ameziane A, Ghidey W, van Rhoon GC, van der Zee J:
Re-irradiation and hyperthermia after surgery for recurrent breast cancer.
Radiother Oncol. 2013 Nov;109(2):188-93.

Müller AC, Eckert F, Heinrich V, Bamberg M, Brucker S, Hehr T:
Re-surgery and chest wall re-irradiation for recurrent breast cancer: a second curative approach.
BMC Cancer. 2011 May 25;11:197.

Van Der Zee J, De Bruijne M, Mens JW, Ameziane A, Broekmeyer-Reurink MP, Drizdal T, Linthorst M, Van Rhoon GC:
Reirradiation combined with hyperthermia in breast cancer recurrences: overview of experience in Erasmus MC.
Int J Hyperthermia. 2010;26(7):638-48.

Zagar TM, Oleson JR, Vujaskovic Z, Dewhirst MW, Craciunescu OI, Blackwell KL, Prosnitz LR, Jones EL:
Hyperthermia for locally advanced breast cancer.
Int J Hyperthermia. 2010;26(7)



Combined RT/HT of radio-induced angiosarcoma

Depla AL, Scharloo-Karels CH, de Jong MA, Oldenborg S, Kolff MW, Oei SB, van Coevorden F, van Rhoon GC, Baartman EA, Scholten RJ, Crezee J, van Tienhoven G:
Treatment and prognostic factors of radiation-associated angiosarcoma (RAAS) after primary breast cancer: a systematic review.
Eur J Cancer. 2014 Jul;50(10):1779-88.

Linthorst M, van Geel AN, Baartman EA, Oei SB, Ghidey W, van Rhoon GC, van der Zee J:
Effect of a combined surgery, re-irradiation and hyperthermia therapy on local control rate in radio-induced angiosarcoma of the chest wall.
Strahlenther Onkol. 2013 May;189(5):387-93.

de Jong MA, Oldenborg S, Bing Oei S, Griesdoorn V, Kolff MW, Koning CCE, van Tienhoven G:
Reirradiation and hyperthermia for radiation-associated sarcoma.
Cancer. 2012, 118(1), 180-187.



Combined RT/HT of malignant melanoma

Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM:
Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology.
Lancet. 1995 Mar 4;345(8949):540-3.

Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM:
Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology. 1996.
Int J Hyperthermia. 2009 Aug;25(5):323-34.



Other selected publications on locoregional HT in oncology

Kok HP, Cressman ENK, Ceelen W, Brace CL, Ivkov R, Grüll H, Ter Haar G, Wust P, Crezee J:
Heating Technology for Malignant Tumors: A Review.
Int J Hyperthermia. 2020;37(1):711-741. doi: 10.1080/02656736.2020.1779357

Datta NR, Kok HP, Crezee H, Gaipl US, Bodis S:
Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses.
Front Oncol. 2020 Jun;10:819. doi:10.3389/fonc.2020.00819

Rhoon GV, Franckena M, Hagen TT:
A moderate thermal dose is sufficient for effective free and TSL based thermochemotherapy.
Advanced Drug Delivery Reviews. 2020; Mar. doi:10.1016/j.addr.2020.03.006

Peeken JC, Vaupel P, Combs SE:
Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?
Front Oncol. 2017 Jun 30;7:132

Oei AL, Vriend LE, Crezee J, Franken NA, Krawczyk PM:
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.
Radiat Oncol. 2015 Aug 7;10:165

Vaupel P, Kelleher DK:
Pathophysiological and vascular characteristics of tumors and their importance for hyperthermia: heterogeneity ist the key issue.
Int J Hyperthermia 2010; 26(3):211-223

van der Zee J, Vujaskovic Z, Kondo M, Sugahara T:
The Kadota Fund International Forum 2004 - clinical group consensus.
Int J Hyperthermia. 2008 Mar;24(2):111-22.

Horsman MR, Overgaard J:
Hyperthermia: A potent enhancer of radiotherapy.
Clin Oncol (R Coll Radiol),2007, 19:418-426

Dewhirst MW, Vujaskovic Z, Jones E, Thrall D:
Re-setting the biologic rationale for thermal therapy.
Int J Hyperthermia. 2005 Dec;21(8):779-90




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