In infectious diseases, natural fever stimulates a most effective immune response.

Using medical hyperthermia devices, controlled heating of targeted areas or even the whole body shows considerable potential in the treatment of various chronic and malignant diseases.

In oncology, hyperthermia can act as a potent sensitizer for radio-, chemo-, and immunotherapy by (re-)oxygenation, inhibition of DNA repair, and stimulation of antitumor immune response.

Water-filtered infrared A (wIRA) is the most effective way of contact-free thermal energy input into human tissue.

Using sealed water cuvettes, wIRA mimics the sun’s thermal irradiation in a humid, life-friendly atmosphere. Water molecules filter out the wavelengths which would be absorbed in the outermost layers of the skin. Thus, a higher energy input and penetration depth can be achieved.

Springer; 2022
OPEN ACCESS

Selected chapters:

• Müller W et al:
  From Sun to Therapeutic wIRA
• Piazena H et al:
  Physical and Photobiological Basics of wIRA-Hyperthermia
• Müller W et al:
  Thermography and Thermometry in wIRA-Hyperthermia
• Thomsen AR et al:
  Temperature Profiles and Oxygenation Status in Human Skin and Subcutis Upon Thermography-Controlled
  wIRA-Hyperthermia
• Notter et al:
  Thermography-Controlled, Contact-Free wIRA-Hyperthermia Combined with Hypofractionated Radiotherapy for Large-Sized Lesions of Unresectable, Locally Recurrent Breast Cancer
• Crezee J et al:
  Combined Use of wIRA and Microwave or Radiofrequency Hyperthermia
• Zschaeck S et al:
  Whole-Body Hyperthermia in Oncology: Renaissance in the Immunotherapy Era?
• Multhoff G et al:
  Mild Hyperthermia Induced by Water-Filtered Infrared A Irradiation: A Potent Strategy to Foster Immune Recognition and Anti-Tumor Immune Responses in Superficial Cancers?
• Heckel-Reusser S:
  Whole-Body Hyperthermia (WBH): Historical Aspects, Current Use, and Future Perspectives.
• Knobel A et al:
  Whole-Body Hyperthermia (WBH) in Psychiatry